DataJoint has achieved Built-On status with Databricks.

  • Agents are Brains. They Need Bodies.

    Agents are Brains. They Need Bodies.

    Agents are Brains. They Need Bodies.

    Imagine a brain in a jar. It's able to reason and process information but it can't do anything with that capability because it has no way to reach the real world. No hands to act, no eyes to gather new information, no way to know what happened after the last thing it thought.

    AI agents have the same problem.

    The conversation around agentic AI has focused almost entirely on the brain i.e., the model, the reasoning, the prompting, the orchestration logic. This all makes sense, since the brain is the exciting part. But agents don't operate in isolation. They operate inside systems, on real data and in real workflows. If those systems aren't built to support them, the agent's intelligence doesn't matter.

    The body is the infrastructure. And most teams haven't built one.


    What agents can't do on their own

    In most organizations when agents get deployed into a workflow, the agent has no reliable way to know what the organization actually knows. This becomes tribal knowledge. That is, the information that lives in people's heads rather than in systems. Which file naming convention does the team actually follow?

    What does "processed" mean in this pipeline? Why does this dataset have a duplicate column? This is the knowledge gap that makes agents frustrating in practice. Contrary to popular belief, it isn't the failure of the model itself but the environment the model is operating in. Agents can't read minds, they read whatever they can actually access. And most of the critical context about how a workflow operates isn't accessible to them.

    The result: agents that hallucinate conventions they can't verify, miss dependencies that aren't documented and produce outputs that are plausible but inaccurate.


    The first half of the body: context

    If you want agents to work reliably, the first thing to build is a curated context layer. Importantly, not documentation for human readers. Documentation for agents. A corpus of information that is structured and current with machine-readable representations of how your system works including what data exists, how it was produced, what the rules are and what's allowed.

    Think of this as a Context Harness. The idea is that agents shouldn't have to reconstruct the state of the world from scratch every time they act. They should be handed a harness, a structured interface to the knowledge they need, so they can spend their capability on the actual task instead of guessing at the environment.


    The second half: determinism

    If context tells agents what the world is, determinism ascertains what they can safely do in it.

    This is where most infrastructure discussions stop short. They get context right but don't enforce any structure on the agent's actions. The agent has good information but no constraints on how it uses that information, which means a mistake can propagate silently, a failed step can be retried with side effects and there's no way to know what the agent actually did without going back through logs.

    Here are five properties that make an agent's operating environment work the way it needs to:

    These five properties don't constrain what agents can accomplish, they constrain how agents can fail. That becomes the difference between an agent that augments a workflow and one that destabilizes it.


    What this looks like in practice

    With DataJoint, scientists design the schema deliberately, and that design is instantiated directly from the code that governs the data. Every arrow in the pipeline diagram is a real enforced dependency. An agent reads the schema and knows the full structure of the scientific process, from raw acquisition through every derived analysis, without needing to ask anyone. It can't produce an orphaned result because the integrity constraints won't allow it. It can retry a failed computation because operations are reversible. It can report on the status of any step because the state is observable.

    The schema isn't a record of the science. It is the science.


    The inversion

    When agents operate inside an environment with a real context harness and deterministic infrastructure, their actions are auditable. Every step is traceable. Every output has a provenance chain. The human scientist doesn't have to trust the agent blindly; they can inspect what it did and why.

    This inverts the usual framing around AI and rigor. We tend to assume there's a tradeoff: move fast with AI or maintain discipline without it. But that tradeoff only exists when the infrastructure isn't there. Build the body first and the agent's productivity and the system's rigor compound in parallel.

    AI increases research productivity and rigor not despite operational discipline. Because of it.

    That's the thing most teams miss when they deploy agents and then wonder why results are inconsistent. They bought the brain. They didn't build the body.

  • When Scientific AI Forgets How It Got There

    Pharma R&D has spent the last three years quietly making AI load-bearing. Models now propose targets, score compounds, design assays, summarize literature, and increasingly draft sections of regulatory documents. The conversation has been about capability — what AI can do. The conversation we are not having, and need to, is about provenance — what the institution can prove about how it did it.

    The argument is narrow and specific: scientific AI without deterministic provenance is not just messy. It is institutionally dangerous.

    By deterministic provenance, I mean the ability to point at any AI-derived result — a hit list, a predicted structure, an annotated cohort, a generated experimental protocol — and reconstruct, bit-for-bit, the data, code, model version, parameters, random seeds, and upstream transformations that produced it. Not “logged somewhere.” Not “the analyst remembers.” Reproducible on demand, by someone other than the person who first ran it.

    Most pharma AI today does not meet this bar. Notebooks reference data files whose schemas have since drifted. Foundation models are version-pinned on paper but rarely in practice. Pipelines stitch together SaaS APIs, internal scripts, and curated spreadsheets. The output looks crisp; the lineage is a smear.

    This is fine when AI is a brainstorming partner. It becomes dangerous the moment AI output enters the institutional record — IND-enabling packages, IP filings, partnership data rooms, internal go/no-go decisions. Three failure modes follow.

    First, regulatory exposure. FDA and EMA expectations are converging on reconstructable analyses. “Our model said so” is not a defense if the model, weights, and inputs cannot be reproduced. Sponsors who accelerate with AI but cannot defend the chain of derivation are accumulating a regulatory debt that comes due during inspection, not before.

    Second, audit blindness when programs fail. Most clinical and preclinical programs fail. The institutional value of a failed program is the post-mortem — what did we believe, why did we believe it, where did the evidence break. When AI-derived intermediates cannot be reconstructed, the post-mortem cannot be performed honestly. The organization loses the ability to learn from its own failures, which is the most expensive form of institutional damage.

    Third, decision velocity outrunning evidence integrity. AI compresses cycle times, which is the point. But the same compression means provenance debt accrues faster than humans can repair it. A team can make twelve AI-assisted decisions in the time it used to make one, with one-twelfth the lineage discipline. The danger is not that any one decision is wrong. It is that the organization can no longer tell which decisions rest on which evidence.

    The fix is not more logging. Logging is observational and lossy. Deterministic provenance has to be a property of the system that produces results, not a record kept alongside it — data, code, and computation tracked in the same structure, with versioning and lineage that are queryable and reproducible. Designed in, not bolted on.

    Leaders evaluating AI tooling should ask a single question of every vendor and every internal team: if a regulator, a partner, or a future post-mortem asks how this result was produced, can we rebuild it from if a regulator, a partner, or afuture post-mortem asks how this result was produced, can we rebuild it from first inputs, without depending on the person who ran it? If the honest answer is no, the institution is not adopting AI. It is borrowing against its own credibility.

    The organizations that win the next decade of scientific AI will not be the ones with the largest models. They will be the ones whose AI outputs are still defensible three years after the analyst has left.


    This is the conviction behind how we built the DataJoint platform: provenance as a first-class property of scientific computation, not alogbook kept beside it.

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  • DataJoint Launches Agentic AI Control Layer for Scientific Workflows

    DataJoint Launches Agentic AI Control Layer for Scientific Workflows

    DataJoint today announced the launch of DataJoint Agentic AI, a governed execution layer for scientific workflows that enables semi-autonomous AI operation on rigorously structured, provenance-rich data.

    As pharmaceutical and academic institutions accelerate investment in generative and agentic AI to further innovation, many are confronting a critical constraint: AI systems trained on fragmented, under-described scientific data cannot reliably reproduce, audit, or defend their outputs. In regulated research environments, this lack of context creates material scientific and operational risk.


    DataJoint addresses this challenge at its source

    The platform captures multi-modal scientific data in precisely defined, interconnected frameworks — embedding rich metadata and full computational provenance at the point of every experimental result. By grounding AI agents in this context-rich foundation, DataJoint enables automated workflow execution while preserving reproducibility, traceability, and decision accountability.

    “Scientific AI will only be as trustworthy as the data foundation beneath it,” said Jim Olson, CEO of DataJoint. “We built DataJoint to ensure that every AI-driven insight is grounded in structured provenance and computational context — so that scientific decisions are not just faster, but defensible and reliable.”

    DataJoint’s agentic AI enables semi-autonomous execution of complex, multi-step scientific pipelines across imaging, electrophysiology, genomics, behavioral data, and more — within a governed, reproducible framework built for regulated and research environments. For pharma and biotech, this means faster hypothesis validation and AI-ready datasets that support regulatory confidence. For academic and medical centers, it means scaling sophisticated research without sacrificing rigor. And all for the purpose of accelerating discoveries and speeding innovation.

    For example, an AI agent operating within DataJoint can validate experimental inputs, trigger downstream processing, detect data and structure inconsistencies, and ensure computational reproducibility — all while maintaining a complete, queryable record of decisions and transformations.

    DataJoint’s structured scientific data infrastructure is already deployed in leading academic medical centers and industry research environments, supporting reproducible multi-modal pipelines at scale.


    Industry Showcases

    DataJoint will demonstrate its Agentic AI capabilities at:

    PMWC 2026 (Precision Medicine World Conference)
    March 4–6, 2026 | San Jose, CA

    Lab of the Future USA Congress
    March 2–3, 2026 | Boston, MA

    These events convene leaders in precision medicine, biopharma R&D, and digital laboratory transformation.

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